Willis et al Exercise intensity and hepatokines.pdf (464.44 kB)
Effect of exercise intensity on circulating hepatokine concentrations in healthy men
journal contribution
posted on 2019-02-11, 17:12 authored by Scott Willis, Jack A. Sargeant, Alice ThackrayAlice Thackray, Thomas E. Yates, David StenselDavid Stensel, Guruprasad P. Aithal, James KingJames KingFibroblast growth factor 21 (FGF21), follistatin and leukocyte cell-derived chemotaxin 2 (LECT2) are novel hepatokines which are modulated by metabolic stresses. This study investigated whether exercise intensity modulates the hepatokine response to acute exercise. Ten young, healthy men undertook three 8-h experimental trials: moderate-intensity exercise (MOD; 55% V̇O2 peak), high-intensity exercise (HIGH; 75% V̇O2 peak) and control (CON; rest), in a randomised, counterbalanced order. Exercise trials commenced with a treadmill run of varied duration to match gross exercise energy expenditure between trials (MOD vs HIGH; 2475 ± 70 vs 2488 ± 58 kJ). Circulating FGF21, follistatin, LECT2, glucagon, insulin, glucose and non-esterified fatty acids (NEFA) were measured before exercise and at 0, 1, 2, 4 and 7 h post-exercise. Plasma FGF21 concentrations were increased up to 4 h post-exercise compared to CON (P ≤ 0.022) with greater increases observed at 1, 2 and 4 h post-exercise during HIGH vs MOD (P ≤ 0.025). Irrespective of intensity (P ≥ 0.606), plasma follistatin concentrations were elevated at 4 and 7 h post-exercise (P ≤ 0.053). Plasma LECT2 concentrations were increased immediately post-exercise (P ≤ 0.046) but were not significant after correcting for plasma volume shifts. Plasma glucagon (1 h; P = 0.032) and NEFA (4 and 7 h; P ≤ 0.029) responses to exercise were accentuated in HIGH vs MOD. These findings demonstrate that acute exercise augments circulating FGF21 and follistatin. Exercise-induced changes in FGF21 are intensity-dependent and may support the greater metabolic benefit of high-intensity exercise.
Funding
National Institute for Health Research (NIHR) Leicester and Nottingham Biomedical Research Centres.
History
School
- Sport, Exercise and Health Sciences
Published in
Applied Physiology, Nutrition, and MetabolismVolume
44Issue
10Pages
1065 - 1072Citation
WILLIS, S.A. ... et al, 2019. Effect of exercise intensity on circulating hepatokine concentrations in healthy men. Applied Physiology, Nutrition, and Metabolism, 44 (10), pp.1065-1072.Publisher
NRC Research Press © The authorsVersion
- AM (Accepted Manuscript)
Publisher statement
This paper was accepted for publication in the journal Applied Physiology, Nutrition, and Metabolism and the definitive published version is available at https://doi.org/10.1139/apnm-2018-0818.Acceptance date
2019-02-04Publication date
2019-08-27ISSN
1715-5312eISSN
1715-5320Language
- en