Zhao_Abbott+2nd+Paper+V7+accepted.pdf (2.39 MB)
Effect of two-year degradation on mechanical interaction between a bioresorbable scaffold and blood vessel
journal contribution
posted on 2017-11-23, 14:45 authored by Tianyang Qiu, Ran He, C. Abunassar, S. Hossainy, Liguo ZhaoThis paper aims to evaluate the mechanical behaviour of a bioresorbable polymeric coronary scaffold using finite element method, focusing on scaffold-artery interaction during degradation and vessel remodelling. A series of nonlinear stress-strain responses was constructed to match the experimental measurement of radial stiffness and strength for polymeric scaffolds over 2-year in-vitro degradation times. Degradation process was modelled by incorporating the change of material property as a function of time. Vessel remodelling was realised by changing the size of artery-plaque system manually, according to the clinical data in literature. Over degradation times, stress on the scaffold tended to increase firstly and then decreased gradually, corresponding to the changing yield stress of the scaffold material; whereas the stress on the plaque and arterial layers showed a continuous decrease. In addition, stress reduction was also observed for scaffold, plaque and artery in the simulations with the consideration of vessel remodelling. For the first time, the work offered insights into mechanical interaction between a bioresorbable scaffold and blood vessel during two-year in-vitro degradation, which has significance in assisting with further development of bioresorbable implants for treating cardiovascular diseases.
Funding
The work was financially supported by Abbott Vascular, 3200 Lakeside Drive, Santa Clara, CA 95054, USA.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Journal of the Mechanical Behavior of Biomedical MaterialsVolume
78Pages
254-265Citation
QIU, T. ...et al., 2017. Effect of two-year degradation on mechanical interaction between a bioresorbable scaffold and blood vessel. Journal of the Mechanical Behavior of Biomedical Materials, 78, pp. 254-265.Publisher
© ElsevierVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2017-11-21Publication date
2017-11-21Notes
This paper was published in the journal Journal of the Mechanical Behavior of Biomedical Materials and the definitive published version is available at https://doi.org/10.1016/j.jmbbm.2017.11.031.ISSN
1751-6161Publisher version
Language
- en