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Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial
journal contribution
posted on 2016-06-16, 15:49 authored by Michael Gleeson, Nicolette BishopNicolette Bishop, Lauren StruszczakAims To assess evidence of health and immune benefit by
consumption of a Lactobacillus casei Shirota probiotic in
highly physically active people.
Methods Single-centre, population-based, randomized,
double-blind, placebo-controlled trial. Daily ingestion of
probiotic (PRO) or placebo (PLA) for 20 weeks for n = 243
(126 PRO, 117 PLA) university athletes and games players.
Subjects completed validated questionnaires on upper respiratory
tract infection symptoms (URS) on a daily basis
and on physical activity status at weekly intervals during
the intervention period. Blood samples were collected
before and after 20 weeks of the intervention for determination
of Epstein Barr virus (EBV) and cytomegalovirus
(CMV) serostatus and antibody levels.
Results URS episode incidence was unexpectedly low
(mean 0.6 per individual) and was not significantly different
on PRO compared with PLA. URS episode duration
and severity were also not influenced by PRO. A significant
time × group interaction effect was observed for plasma
CMV antibody titres in CMV seropositive participants
(p < 0.01) with antibody titre falling in the PRO group
but remaining unchanged in the PLA group over time. A
similar effect was found for plasma EBV antibody titres in
EBV seropositive participants (p < 0.01) with antibody titre
falling in the PRO group but increasing in the PLA group
over time. Conclusions In summary, regular ingestion of PRO did not
reduce URS episode incidence which might be attributable
to the low URS incidence in this study. Regular ingestion
of PRO reduced plasma CMV and EBV antibody titres, an
effect that can be interpreted as a benefit to overall immune
status.
Funding
This study was fully sponsored by Yakult Honsha Co., Ltd., Japan.
History
School
- Sport, Exercise and Health Sciences
Published in
European Journal of Applied PhysiologyCitation
GLEESON, M., BISHOP, N. and STRUSZCZAK, L., 2016. Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial. European Journal of Applied Physiology, 116 (8), pp. 1555-1563.Publisher
Springer Verlag / © The AuthorsVersion
- VoR (Version of Record)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/Acceptance date
2016-06-07Publication date
2016Notes
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons. org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.ISSN
1439-6327Publisher version
Language
- en