AAPS Chen Y.pdf (2.75 MB)
High-speed laser image analysis of plume angles for pressurised metered dose inhalers: the effect of nozzle geometry
journal contribution
posted on 2017-01-06, 09:18 authored by Yang Chen, Paul M. Young, Seamus Murphy, David F. Fletcher, Edward LongEdward Long, David Lewis, Tanya Church, Daniela TrainiThe aim of this study is to investigate aerosol plume geometries of pressurised metered dose inhalers (pMDIs) using a high-speed laser image system with different actuator nozzle materials and designs. Actuators made from aluminium, PET and PTFE were manufactured with four different nozzle designs: cone, flat, curved cone and curved flat. Plume angles and spans generated using the designed actuator nozzles with four solution-based pMDI formulations were imaged using Oxford Lasers EnVision system and analysed using EnVision Patternate software. Reduced plume angles for all actuator materials and nozzle designs were observed with pMDI formulations containing drug with high co-solvent concentration (ethanol) due to the reduced vapour pressure. Significantly higher plume angles were observed with the PTFE flat nozzle across all formulations, which could be a result of the nozzle geometry and material’s hydrophobicity. The plume geometry of pMDI aerosols can be influenced by the vapour pressure of the formulation, nozzle geometries and actuator material physiochemical properties.
Funding
This research was supported by the Australian Research Council Linkage Project funding scheme (project number ARC-LP100200156) and Chiesi Ltd, Chippenham, Wiltshire, UK. Professor Traini is the recipient of an Australian Research Council Future Fellowship (project number FT12010063). Professor Young is the recipient of an Australian Research Council Future Fellowship (project number FT110100996).
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
AAPS PharmSciTechVolume
18Pages
782-789Citation
CHEN, Y. ... et al, 2016. High-speed laser image analysis of plume angles for pressurised metered dose inhalers: the effect of nozzle geometry. AAPS PharmSciTech, 18 (3), pp. 782–789.Publisher
Springer © American Association of Pharmaceutical ScientistsVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2016-06-01Publication date
2016-06-17Notes
The final publication is available at Springer at http://dx.doi.org/10.1208/s12249-016-0564-5ISSN
1530-9932eISSN
1530-9932Publisher version
Language
- en