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How do coil configuration and packing density influence intra-aneurysmal hemodynamics?
journal contribution
posted on 2019-10-31, 09:48 authored by HG Morales, Minsuok KimMinsuok Kim, EE Vivas, M-C Villa-Uriol, I Larrabide, T Sola, L Guimaraens, AF FrangiBACKGROUND AND PURPOSE: Endovascular coiling is a well-established therapy for treating intracranial aneurysms. Nonetheless, postoperative hemodynamic changes induced by this therapy remain
not fully understood. The purpose of this work is to assess the influence of coil configuration and
packing density on intra-aneurysmal hemodynamics.
MATERIALS AND METHODS: Three 3D rotational angiography images of 3 intracranial aneurysms
before and after endovascular coiling were used. For each aneurysm, a 3D representation of the
vasculature was obtained after the segmentation of the images. Afterward, a virtual coiling
technique was used to treat the aneurysm geometries with coil models. The aneurysms were
coiled with 5 packing densities, and each was generated by using 3 coil configurations. Computational fluid dynamics analyses were carried out in both untreated and treated aneurysm geometries. Statistical tests were performed to evaluate the relative effect of coil configuration on local
hemodynamics.
RESULTS: The intra-aneurysmal blood flow velocity and wall shear stress were diminished as packing
density increased. Aneurysmal flow velocity was reduced <50% due to the first inserted coils (packing
density <12%) but with a high dependency on coil configuration. Nonsignificant differences (P > .01)
were found in the hemodynamics due to coil configuration for high packing densities (near 30%). A
damping effect was observed on the intra-aneurysmal blood flow waveform after coiling.
CONCLUSIONS: Intra-aneurysmal hemodynamics are altered by coils. Coil configuration might reduce
its influence on intra-aneurysmal hemodynamics as the packing density increases until an insignificant
influence could be achieved for high packing densities.
Funding
CENIT program, as part of CDTEAM and cvREMOD projects funded by the Spanish CDTI
@neurIST Project (IST-2005-027703)
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
American Journal of NeuroradiologyVolume
32Issue
10Pages
1935 - 1941Publisher
American Society of Neuroradiology (ASNR)Version
- VoR (Version of Record)
Acceptance date
2011-03-05Publication date
2011-11Copyright date
2019ISSN
0195-6108eISSN
1936-959XPublisher version
Language
- en
Depositor
Dr Minsuok Kim Deposit date: 28 October 2019Usage metrics
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