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Infant weight gain and adolescent body mass index: comparison across two British cohorts born in 1946 and 2001
journal contribution
posted on 2018-04-13, 11:00 authored by Will JohnsonWill Johnson, David Bann, Rebecca HardyObjective
To investigate how the relationship of infant weight gain with adolescent body mass index (BMI) differs for individuals born during compared to before the obesity epidemic era.
Design
Data from two British birth cohorts, the 1946 National Survey of Health and Development (NSHD, n = 4,199) and the 2001 Millennium Cohort Study (MCS, n = 9,417), were used to estimate and compare associations of infant weight gain between ages 0-3 years with adolescent outcomes.
Main outcome measures
BMI Z-scores and overweight/ obesity at ages 11 and 14 years.
Results
Infant weight gain, in Z-scores, was positively associated with adolescent BMI Z-scores in both cohorts. Non-linearity in the MCS meant that associations were only stronger than in the NSHD when infant weight gain was above -1 Z-score. Using decomposition analysis, between-cohort differences in association accounted for 20-30% of the differences (secular increases) in BMI Z-scores, although the underlying estimates were not precise with 95% confidence intervals (CI) crossing zero. Conversely, between-cohort differences in the distribution of infant weight gain accounted for approximately 9% of the differences (secular increases) in BMI Z-scores, and the underlying estimates were precise with 95% CI not crossing zero. Relative to normal weight gain (change of -0.67 to +0.67 Z-scores between ages 0-3 years), very rapid infant weight gain (> 1.34), but not rapid weight gain (+0.67 to +1.34), was associated with higher BMI Z-scores more strongly in the MCS (β = 0.790; 95% CI = 0.717, 0.862 at age 11 years) than the NSHD (0.573; 0.466, 0.681); p < 0.001 for between-cohort difference. The relationship of slow infant weight gain (< -0.67) with lower adolescent BMI was also stronger in the MCS. Very rapid or slow infant weight gain were not, however, more strongly associated with increased risk of adolescent overweight/ obesity or thinness, respectively, in the more recently born cohort.
Conclusions
Greater infant weight gain, at the middle/ upper-end of the distribution, was more strongly associated with higher adolescent BMI among individuals born during (compared to before) the obesity epidemic. Combined with a secular change toward greater infant weight gain, these results suggest that there are likely to be associated negative consequences for population-level health and wellbeing in the future, unless effective interventions are developed and implemented.
History
School
- Sport, Exercise and Health Sciences
Published in
Archives of Disease in ChildhoodCitation
JOHNSON, W.O., BANN, D. and HARDY, R., 2018. Infant weight gain and adolescent body mass index: comparison across two British cohorts born in 1946 and 2001. Archives of Disease in Childhood, 103(10), pp.974-980.Publisher
© The authors. Published by BMJ Publishing GroupVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2018-03-27Publication date
2018-04-19Notes
This paper was accepted for publication in the journal Archives of Disease in Childhood and the definitive published version is available at http://dx.doi.org/10.1136/archdischild-2017-314079ISSN
0003-9888Publisher version
Language
- en