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Lactose: a definitive guide to polymorph determination
journal contribution
posted on 2014-08-06, 12:52 authored by Joanne H. Kirk, Sandie DannSandie Dann, C.G. BlatchfordLactose is a well-known molecule capable of forming a number of different polymorphs with varied chemical and physical properties. To date,
no definitive guide for distinguishing between polymorphs using simple analytical techniques has been available. The information presented in this
article aims to provide a conclusive guide for identifying the polymorphs of lactose and to successfully unravel years of contradictory research.
Data have been collected on single phase polymorphs, prepared from an identical source, adopting the use of in situ and ex situ powder X-ray
diffraction, CCD-Raman, FT-IR and 13C–1H cross-polarisation magic angle spinning NMR (CP-MASNMR) spectroscopy, in order to provide
simple methods to discriminate between the polymorphs.
Funding
The authors wish to acknowledge 3M Health Care for studentship of JHK.
History
School
- Science
Department
- Chemistry
Published in
INTERNATIONAL JOURNAL OF PHARMACEUTICSVolume
334Issue
1-2Pages
103 - 114 (12)Citation
KIRK, J.H., DANN, S.E. and BLATCHFORD, C.G., 2007. Lactose: a definitive guide to polymorph determination. International Journal of Pharmaceutics, 334(1-2), pp.103-114.Publisher
© ElsevierVersion
- NA (Not Applicable or Unknown)
Publication date
2007Notes
This item is Closed Access.ISSN
0378-5173Publisher version
Language
- en