nihms-73159.pdf (1.09 MB)
Morphology parameters for intracranial aneurysm rupture risk assessment
journal contribution
posted on 2019-10-31, 11:28 authored by Sujan Dhar, Markus Tremmel, J Mocco, Minsuok KimMinsuok Kim, Junichi Yamamoto, Adnan H Siddiqui, L Nelson Hopkins, Hui MengOBJECTIVE—The aim of this study is to identify image-based morphological parameters that
correlate with human intracranial aneurysm (IA) rupture.
METHODS—For 45 patients with terminal or sidewall saccular IAs (25 unruptured, 20 ruptured),
three-dimensional geometries were evaluated for a range of morphological parameters. In addition
to five previously studied parameters (aspect ratio, aneurysm size, ellipticity index, nonsphericity
index, and undulation index), we defined three novel parameters incorporating the parent vessel
geometry (vessel angle, aneurysm [inclination] angle, and [aneurysm-to-vessel] size ratio) and
explored their correlation with aneurysm rupture. Parameters were analyzed with a two-tailed
independent Student's t test for significance; significant parameters (P < 0.05) were further examined
by multivariate logistic regression analysis. Additionally, receiver operating characteristic analyses
were performed on each parameter.
RESULTS—Statistically significant differences were found between mean values in ruptured and
unruptured groups for size ratio, undulation index, nonsphericity index, ellipticity index, aneurysm
angle, and aspect ratio. Logistic regression analysis further revealed that size ratio (odds ratio, 1.41;
95% confidence interval, 1.03−1.92) and undulation index (odds ratio, 1.51; 95% confidence interval,
1.08−2.11) had the strongest independent correlation with ruptured IA. From the receiver operating
characteristic analysis, size ratio and aneurysm angle had the highest area under the curve values of
0.83 and 0.85, respectively.
CONCLUSION—Size ratio and aneurysm angle are promising new morphological metrics for IA
rupture risk assessment. Because these parameters account for vessel geometry, they may bridge the
gap between morphological studies and more qualitative location-based studies.
Funding
National Science Foundation under Grant BES-0302389
National Institute of Health under Grants NS047242, EB002873, and NS043924.
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
NeurosurgeryVolume
63Issue
2Pages
185 - 197Publisher
Oxford University Press (OUP)Version
- AM (Accepted Manuscript)
Publisher statement
This is a pre-copyedited, author-produced version of an article accepted for publication in Neurosurgery following peer review. The version of record Dhar, S…. et al., 2008. Morphology parameters for intracranial aneurysm rupture risk assessment. Neurosurgery, 63(2), pp. 185-197 is available online at: https://doi.org/10.1227/01.neu.0000316847.64140.81Publication date
2008-08-01ISSN
0148-396XeISSN
1524-4040Publisher version
Language
- en
Depositor
Dr Minsuok Kim Deposit date: 28 October 2019Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC