UnmarkedMS_AiQallaf&Das.pdf (254.65 kB)
Optimization of square microneedle arrays for increasing drug permeability in skin
journal contribution
posted on 2014-12-22, 14:33 authored by Barrak Al-Qallaf, Diganta DasDiganta DasMicroneedles array is a new transdermal drug delivery technique designed to create holes in the epidermis and penetrate the stratum corneum, thus avoiding the high resistance of this barrier. Microneedles have been shown to increase the skin permeability of drugs with no or little pain. However, the skin permeability of epidermis while using microneedle arrays has yet to be fully studied. In some cases, microneedle and microneedle array designs which were developed based on certain criteria (e.g., material of the microneedles) have to be related to other criteria (e.g., drug permeability in skin, skin thickness, etc.). Therefore, in order to determine the optimum design of the microneedle arrays, the effect of different factors (e.g., number of the microneedle, surface area of the patch, etc.) along with skin permeability by using microneedles should be determined accurately. In this work, an optimization framework for transdermal delivery of high molecular weight drug from microneedle is presented. The outputs of this framework have allowed us to identify the optimum design of various microneedles. Data from this optimization algorithm is then used to predict skin permeability of high molecular weight injected into the skin from a microneedle system. The effect of the optimized microneedles on blood drug concentration has been determined. The outcome of this study is useful to propose an optimum design based on different measurement (e.g., variation of skin thickness) for transdermal delivery of drugs.
Funding
The authors would like to thank MOI (Ministry of Interior), Kuwait for their funding of this work.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
CHEMICAL ENGINEERING SCIENCEVolume
63Issue
9Pages
2523 - 2535 (13)Citation
AL-QALLAF, B. and DAS, D.B., 2008. Optimization of square microneedle arrays for increasing drug permeability in skin. Chemical Engineering Science, 63 (9), pp. 2523 - 2535.Publisher
© Elsevier LtdVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2008Notes
NOTICE: this is the author’s version of a work that was accepted for publication in Chemical Engineering Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version will be subsequently published in Chemical Engineering Science DOI:10.1016/j.ces.2008.02.007ISSN
0009-2509Publisher version
Language
- en