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PLGA particle production for water soluble drug encapsulation: degradation and release behaviour

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journal contribution
posted on 11.12.2009, 14:27 by G. Gasparini, Richard Holdich, S.R. Kosvintsev
Particles for subcutaneous depot use encapsulating a model water soluble drug have been produced from poly(lactic-glycolic acid) (PLGA) using a membrane emulsification – solvent evaporation technique. The release behaviour, mainly the change in size and inner morphology are reported. During release, the particles initially swelled in size, then reduced. A diffusion based model, taking in to account the change in particle size, is presented. Surface erosion is evident from the particle size and image evidence, and the diffusion model provides a fit to the data even during the surface erosion period, suggesting that the model drug diffuses before the particle degrades.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

GASPARINI, G., HOLDICH, R.G. and KOSVINTSEV, S.R., 2010. PLGA particle production for water soluble drug encapsulation: degradation and release behaviour. Colloids and Surfaces B: Biointerfaces, 75 (2), pp. 557-564.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publication date

2010

Notes

This is a journal article. It was published in the journal, Colloids and Surfaces B: Biointerfaces [© Elsevier] and the definitive version is available at: www.elsevier.com/locate/colsurfb

ISSN

0927-7765

Language

en

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