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Patient-specific computational hemodynamics of intracranial aneurysms from 3D rotational angiography and CT angiography: An in vivo reproducibility study
journal contribution
posted on 2019-10-31, 10:14 authored by AJ Geers, I Larrabide, AG Radaelli, H Bogunovic, Minsuok KimMinsuok Kim, HAF Gratama van Andel, CB Majoie, E VanBavel, AF FrangiBACKGROUND AND PURPOSE: Patient-specific simulations of the hemodynamics in intracranial aneurysms can be constructed by using image-based vascular models and CFD techniques. This work
evaluates the impact of the choice of imaging technique on these simulations.
MATERIALS AND METHODS: Ten aneurysms, imaged with 3DRA and CTA, were analyzed to assess the
reproducibility of geometric and hemodynamic variables across the 2 modalities.
RESULTS: Compared with 3DRA models, we found that CTA models often had larger aneurysm necks
(P=.05) and that most of the smallest vessels (between 0.7 and 1.0 mm in diameter) could not be
reconstructed successfully with CTA. With respect to the values measured in the 3DRA models, the flow
rate differed by 14.1 ± 2.8% (mean ± SE) just proximal to the aneurysm and 33.9 ± 7.6% at the aneurysm
neck. The mean WSS on the aneurysm differed by 44.2 ± 6.0%. Even when normalized to the parent
vessel WSS, a difference of 31.4 ± 9.9% remained, with the normalized WSS in most cases being larger
in the CTA model (P =.04). Despite these substantial differences, excellent agreement (k ≥ 0.9) was found
for qualitative variables that describe the flow field, such as the structure of the flow pattern and the flow
complexity.
CONCLUSIONS: Although relatively large differences were found for all evaluated quantitative hemodynamic variables, the main flow characteristics were reproduced across imaging modalities.
Funding
@neurIST Integrated Project (cofinanced by the European Commission through contract no. IST-027703)
Spanish Ministry of Science and Innovation
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
American Journal of NeuroradiologyVolume
32Issue
3Pages
581 - 586Publisher
American Society of Neuroradiology (ASNR)Version
- VoR (Version of Record)
Rights holder
© American Journal of NeuroradiologyPublisher statement
This is an Open Access Article. It is published by ASNR under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2010-07-20Publication date
2011-03Copyright date
2011ISSN
0195-6108eISSN
1936-959XPublisher version
Language
- en
Depositor
Dr Minsuok Kim Deposit date: 28 October 2019Usage metrics
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