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Probing the thermal transitions of lactobionic acid and effects of sample history by DSC analysis

journal contribution
posted on 06.01.2020 by Leno Mascia, Alessandro Coroli, Elisa Mele
© 2019 American Pharmacists Association® We report the results of an ad hoc evaluation of the thermal transition and physical state of lactobionic acid, carried out by differential scanning calorimetry, which was motivated by the confusion about its physical state in relation to the “melting point.” This work establishes that lactobionic acid is a molecular glass characterized by a glass-liquid transition at around 125°C and 2 minor transitions, respectively, at around 70°C and 40°C. The temperature at which these latter transitions appear and the intensity of the enthalpic peaks, associated with physical aging, are sensitive to the thermal history of the sample and to the presence of small quantities of absorbed water.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Journal of Pharmaceutical Sciences

Volume

108

Issue

12

Pages

3781 - 3784

Publisher

ELSEVIER SCIENCE INC

Version

AM (Accepted Manuscript)

Rights holder

© American Pharmacists Association

Publisher statement

This paper was accepted for publication in the journal Journal of Pharmaceutical Sciences and the definitive published version is available at https://doi.org/10.1016/j.xphs.2019.09.017

Acceptance date

18/09/2019

Publication date

2019-09-23

Copyright date

2019

ISSN

0022-3549

eISSN

1520-6017

Language

en

Location

United States

Depositor

Dr Elisa Mele Deposit date: 21 December 2019

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