Polymer paper manuscript accpeted verison.pdf (1.37 MB)
Quantifying the mechanical properties of polymeric tubing and scaffold using atomic force microscopy and nanoindentation
journal contribution
posted on 2019-02-15, 14:40 authored by Raasti Naseem, Liguo Zhao, Vadim SilberschmidtVadim Silberschmidt, Yang LiuYang Liu, S.K. Eswaran, S. HossainyMeasurement of mechanical parameters of polymeric scaffolds presents a significant challenge due to their intricate shape and small characteristics dimensions of their elements – around 100μm. In this study, mechanical properties of polymeric tubing and scaffold, made of biodegradable poly (l-lactic) acid (PLLA), were characterised using atomic force microscopy (AFM) and nanoindentation, complemented with tensile testing. AFM was employed to assess the properties of the tube and scaffold locally, whilst nanoindentation produced results with a dependency on the depth of indentation. As a result, the AFM-measured elastic modulus differs from the nanoindentation data due to a substantial difference in indentation depth between the two methods. With AFM, a modulus between 2 and 2.5 GPa was measured, while a wide range was obtained from nanoindentation on both the tube and scaffold, depending on the indentation scale. Changes in the elastic modulus with in-vitro degradation and ageing were observed over the one-year period. To complement the indentation measurements, tensile testing was used to study the structural behaviour of the tube, demonstrating the yielding, hardening and fracture properties of the material.
Funding
This work is funded by the British Heart Foundation PhD research project (Grant number: FS/15/21/31424; Title: Towards controlling the mechanical performance of polymeric bioresorbable vascular scaffold during biodegradation).
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
Polymer Engineering and ScienceCitation
NASEEM, R. ... et al, 2019. Quantifying the mechanical properties of polymeric tubing and scaffold using atomic force microscopy and nanoindentation. Polymer Engineering and Science, 59 (5), pp. 1084-1091.Publisher
Wiley © Society of Plastics EngineersVersion
- AM (Accepted Manuscript)
Publisher statement
This is the peer reviewed version of the following article: NASEEM, R. ... et al, 2019. Quantifying the mechanical properties of polymeric tubing and scaffold using atomic force microscopy and nanoindentation. Polymer Engineering and Science, 59 (5), pp. 1084-1091, which has been published in final form at https://doi.org/10.1002/pen.25085. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Acceptance date
2019-02-08Publication date
2019-03-04ISSN
0032-3888eISSN
1548-2634Publisher version
Language
- en