Regulation of metabolic disease-associated inflammation by nutrient sensors
2018-07-03T08:52:16Z (GMT) by
Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β31 cell dysfunction. Herein we review the mechanisms by which nutrients modulate obesity associated inflammation.