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Spinal cord injury level influences acute plasma caffeine responses

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posted on 11.10.2016 by Terri Graham, Thomas A.W. Paulson, Claudio Perret, Keith Tolfrey, Philip Cordery, Vicky Goosey-Tolfrey
Purpose. To investigate the absorption curve and acute effects of caffeine at rest in individuals with no spinal cord injury (SCI), paraplegia (PARA) and tetraplegia (TETRA). Methods. Twenty-four healthy males (8 able-bodied (AB), 8 PARA and 8 TETRA) consumed 3 mg∙kg-1 caffeine anhydrous (CAF) in a fasted state. Plasma caffeine [CAF], glucose, lactate, free-fatty acid [FFA] and catecholamine concentrations were measured during a 150 min rest period. Results. Peak [CAF] was greater in TETRA (21.5 µM) compared to AB (12.2 µM) and PARA (15.1 µM), and mean peak [CAF] occurred at 70, 80 and 80 min, respectively. Moderate and large ES were revealed for TETRA compared to PARA and AB (-0.55 and -1.14, respectively) for the total area under the [CAF] versus time curve. Large inter-individual responses were apparent in SCI groups. The change in plasma catecholamine concentrations following CAF did not reach significance (p>0.05) however both adrenaline and noradrenaline concentrations were lowest in TETRA. Significant increases in [FFA] were seen over time (p<0.0005) but there was no significant influence of SCI level. Blood lactate concentration reduced over time (p=0.022) whereas blood glucose concentration decreased modestly (p=0.695), and no difference between groups was seen (p>0.05). Conclusion. Level of SCI influenced the caffeine absorption curve and there was large inter-individual variation within and between groups. Individual curves should be considered when using caffeine as an ergogenic aid in athletes with an SCI. The results indicate TETRA should trial low doses in training and PARA may consider consuming caffeine greater than 60 min prior to exercise performance. The study also supports caffeine’s direct effect on adipose tissue, which is not secondary to catecholamine release.

History

School

  • Sport, Exercise and Health Sciences

Published in

Medicine & Science in Sport & Exercise

Citation

GRAHAM-PAULSON, T.S. ...et al., 2017. Spinal cord injury level influences acute plasma caffeine responses. Medicine & Science in Sport & Exercise, 49(2), pp.363-370.

Publisher

© the American College of Sports Medicine. Published by Lippincott, Williams & Wilkins

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

19/09/2016

Publication date

2017

Notes

This is a non-final version of an article published in final form in GRAHAM-PAULSON, T.S. ...et al., 2017. Spinal cord injury level influences acute plasma caffeine responses. Medicine & Science in Sport & Exercise, 49(2), pp.363-370..

ISSN

0195-9131

eISSN

1530-0315

Language

en

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