Thesis-1999-McFadyen.pdf (5.91 MB)
Structure–activity relationships of opioid ligands
thesis
posted on 2018-05-30, 08:31 authored by Iain J. McFadyenThere are three different types of opioid receptor, namely mu, delta and kappa.
Morphine and related clinically useful analgesics exert their actions through the mu opioid
receptor. Such compounds represent a huge structural diversity, including both
peptides and alkaloids. Nevertheless, there exists a common pharmacophore
comprising two critical features, namely an amine nitrogen and an aromatic ring,
usually with a hydroxyl substituent; the spatial relationship between them is also vital. [Continues.]
Funding
Engineering and Physical Sciences Research Council.
History
School
- Science
Department
- Chemistry
Publisher
© Iain James McFadyenPublisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
1999Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.Language
- en