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The effect of a 12-week resistance training intervention on leukocyte telomere length
journal contribution
posted on 2020-06-11, 12:29 authored by Matthew Nickels, Sarabjit MastanaSarabjit Mastana, David HunterDavid Hunter, Matthew Denniff, Veryan Codd, Liz AkamLiz AkamTelomere dynamics are an active biological process and positive lifestyle factors such as exercise are proposed to potentiate their length. The aim of this study was to investigate the effect of a low-resistance, high-repetition resistance training intervention on leukocyte telomere length (LTL) and associated health parameters. 23 sedentary middle-aged adults volunteered for this study (16 female/7 male; age = 51.5 ± 4.9 years) and performed two one-hour sessions of Les Mills BODYPUMP™ per week for 12 weeks. Outcome measures were taken at baseline, after the training intervention and at 12-month follow-up. LTL remained unchanged following the training intervention (pre 0.819 ± 0.121 vs post 0.812 ± 0.114, p = 0.420), despite a borderline significant increase in hTERT expression (p = 0.050). Circulating levels of tumour necrosis factor alpha were reduced after the intervention (p = 0.001). At 12-month follow-up, subjects who returned to a sedentary lifestyle (n = 10) displayed shorter telomeres compared to their pre (p = 0.036) values. In conclusion, no changes were observed in LTL following the 12-week training intervention, despite improvements in molecular parameters associated with telomere dynamics. It appears continued long-term exercise (>12 months) is necessary to preserve LTL in previously sedentary individuals.
History
School
- Sport, Exercise and Health Sciences
Published in
HeliyonVolume
6Issue
6Pages
e04151Publisher
Elsevier BVVersion
- VoR (Version of Record)
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© The authorsPublisher statement
This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/Acceptance date
2020-06-02Publication date
2020-06-10Copyright date
2020ISSN
2405-8440Publisher version
Language
- en
Depositor
Dr Sarabjit Mastana . Deposit date: 10 June 2020Article number
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