Markey_the-effect-of-quantity-and-quality-of-dietary-fat-intake-on-subcutaneous-white-adipose-tissue-inflammatory-responses.pdf (2.15 MB)
The effect of quantity and quality of dietary fat intake on subcutaneous white adipose tissue inflammatory responses
journal contribution
posted on 2020-02-06, 14:03 authored by Rebecca Dewhurst-Trigg, Carl Hulston, Oonagh MarkeyOonagh MarkeyThe global prevalence of obesity and
obesity-associated cardiometabolic diseases is a significant public health
burden. Chronic low-grade inflammation in metabolic tissues such as white
adipose tissue (WAT) is linked to obesity and may play a role in disease
progression. The overconsumption of dietary fat has been suggested to modulate
the WAT inflammatory environment. It is also recognised that fats varying in
degree of fatty acid (FA) saturation may elicit differential WAT inflammatory
responses. This information has originated predominantly from animal or cell
models and translation into humans in vivo remains limited. This review will
summarise human intervention studies investigating the effect of dietary fat quantity
and quality on subcutaneous WAT inflammation, with a specific focus on the toll
like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) and nucleotide-binding and
oligomerisation domain-like receptor, leucine-rich repeat and pyrin
domain-containing 3 (NLRP3) inflammasome molecular signalling pathways. Overall,
firm conclusions are hard to draw regarding the effect of dietary fat quantity
and quality on WAT inflammatory responses due to the heterogeneity of study
designs, composition of the diets and participant cohorts recruited. Previous
studies have predominantly focused on measures of WAT gene expression. It is suggested
that future work includes measures of WAT total content and phosphorylation of
proteins involved in TLR4/NF-κB and NLRP3 signalling as this is more
representative of alterations in WAT physiological function. Understanding pathways linking intake of total fat and specific FAs
with WAT metabolic-inflammatory responses may have important implications for public
health by informing dietary guidelines aimed at cardiometabolic risk reduction
History
School
- Sport, Exercise and Health Sciences
Published in
Proceedings of the Nutrition SocietyVolume
79Issue
4Pages
542 - 556Publisher
Cambridge University Press (CUP)Version
- VoR (Version of Record)
Rights holder
© The AuthorsPublisher statement
This article has been published in a revised form in Proceedings of the Nutrition Society https://doi.org/10.1017/S0029665120000038. This version is published under a Creative Commons CC-BY-NC-ND. No commercial re-distribution or re-use allowed. Derivative works cannot be distributed. © The Authors.Acceptance date
2020-01-06Publication date
2020-02-17Copyright date
2020ISSN
0029-6651eISSN
1475-2719Publisher version
Language
- en
Depositor
Dr Oonagh Markey Deposit date: 6 February 2020Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC