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The selective mono and difunctionalization of carbocyclic cleft molecules with pyridyl groups and X-ray crystallographic analysis
journal contribution
posted on 2014-01-10, 14:32 authored by Priti Jilka, Claire Millington, Mark ElsegoodMark Elsegood, Josef W.A. Frese, Simon J. Teat, Marc KimberMarc KimberThe diesterification and selective mono and dialkylation of carbocyclic analogues of Tröger’s base with pyridyl groups has been achieved in high yield and good selectivity giving access to a novel range of cleft molecules capable of binding events. Reaction conditions for the selective functionalization of this carbocyclic cleft molecule are discussed as well as the solid state structures of these newly synthesized ligands.
History
School
- Science
Department
- Chemistry
Citation
JILKA, P. ... et al, 2010. The selective mono and difunctionalization of carbocyclic cleft molecules with pyridyl groups and X-ray crystallographic analysis. Tetrahedron, 66 (48), pp. 9327 - 9331Publisher
© Elsevier LtdVersion
- AM (Accepted Manuscript)
Publication date
2010Notes
This article was published in the journal Tetrahedron [© Elsevier Ltd]. The definitive version is available at: http://dx.doi.org/10.1016/j.tet.2010.10.027ISSN
0040-4020Publisher version
Language
- en