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Toward integrated management of cerebral aneurysms

journal contribution
posted on 31.10.2019 by MC Villa-Uriol, I Larrabide, JM Pozo, Minsuok Kim, O Camara, M De Craene, C Zhang, AJ Geers, H Morales, H Bogunović, R Cardenes, AF Frangi
In the last few years, some of the visionary concepts behind the virtual physiological human began to be demonstrated on various clinical domains, showing great promise for improving healthcare management. In the current work, we provide an overview of imageand biomechanics-based techniques that, when put together, provide a patient-specific pipeline for the management of intracranial aneurysms. The derivation and subsequent integration of morphological, morphodynamic, haemodynamic and structural analyses allow us to extract patient-specific models and information from which diagnostic and prognostic descriptors can be obtained. Linking such new indices with relevant clinical events should bring new insights into the processes behind aneurysm genesis, growth and rupture. The development of techniques for modelling endovascular devices such as stents and coils allows the evaluation of alternative treatment scenarios before the intervention takes place and could also contribute to the understanding and improved design of more effective devices. A key element to facilitate the clinical take-up of all these developments is their comprehensive validation. Although a number of previously published results have shown the accuracy and robustness of individual components, further efforts should be directed to demonstrate the diagnostic and prognostic efficacy of these advanced tools through large-scale clinical trials.

Funding

@neurIST Integrated Project (co-financed by the European Commission through contract no. IST-027703)

CDTI CENIT-CDTEAM grant funded by the Spanish Ministry of Science and Innovation (MICINN-CDTI)

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volume

368

Issue

1921

Pages

2961 - 2982

Publisher

The Royal Society

Version

VoR (Version of Record)

Rights holder

© The Royal Society

Publication date

2010-06-28

Copyright date

2010

ISSN

1364-503X

eISSN

1471-2962

Language

en

Depositor

Dr Minsuok Kim Deposit date: 28 October 2019

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