James Kusena Thesis .pdf (45.36 MB)
Translational requirements for manufactured dopaminergic neurons for the treatment of Parkinson’s Disease
thesis
posted on 2020-02-06, 09:05 authored by James KusenaAfter decades of research there is now a plethora of cell-based therapies traversing through different phases of clinical trials. However, there remains work to be done regarding optimising the quality and production efficiency of these therapies, as well as economic considerations to validate their commercial viability. This project focuses on the process development of a candidate human embryonic stem cell (hESC) based therapy for Parkinson’s disease (PD) and the related health economics. This work set out to identify the key translational requirements for successful, robust and reproducible manufacture of a cell-based therapy for PD, by optimising a preclinical validated differentiation protocol. [Continues.]
History
School
- Mechanical, Electrical and Manufacturing Engineering
Publisher
Loughborough UniversityRights holder
© James KusenaPublication date
2019Notes
A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of the degree of Doctor of Philosophy of Loughborough University.Language
- en
Supervisor(s)
Samantha L. Wilson ; Robert J. ThomasQualification name
- PhD
Qualification level
- Doctoral
This submission includes a signed certificate in addition to the thesis file(s)
- I have submitted a signed certificate