Mele_Paper NP Fiducial Markers (14 Mar).pdf (866.89 kB)
Ultra-efficient, widely tunable gold nanoparticles-based fiducial markers for X-ray imaging
journal contribution
posted on 2016-11-25, 11:07 authored by G. Maiorano, Elisa MeleElisa Mele, C. Frassanito, E. Restini, Athanassia Athanassiou, P.P. PompaWe show the development of a new class of highly efficient, biocompatible fiducial markers for X-ray imaging and radiosurgery, based on polymer shells encapsulating engineered gold nanoparticle (AuNP)
suspensions. Our smart fabrication strategy enables wide tunability of the fiducial size, shape, and X-ray attenuation performance, up to record values >20 000 Hounsfield units (HU), i.e. comparable to or even higher than bulk gold. We show that the NP fiducials allow for superior imaging both in vitro and in vivo (yet requiring 2 orders of magnitude less material), with strong stability over time and the absence of classical “streak artifacts” of standard bulk fiducials. NP fiducials were probed in vivo, showing exceptional contrast efficiency, even after 2 weeks post-implant in mice.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Materials
Published in
NanoscaleVolume
8Issue
45Pages
18921 - 18927Citation
MAIORANO, G. ...et al., 2016. Ultra-efficient, widely tunable gold nanoparticles-based fiducial markers for X-ray imaging. Nanoscale, 8, 18921.Publisher
© Royal Society of ChemistryVersion
- NA (Not Applicable or Unknown)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2016-10-07Publication date
2016-10-13Notes
This paper was submitted for publication in the journal Nanoscale and the definitive published version is available at http://dx.doi.org/10.1039/C6NR07021CISSN
2040-3364eISSN
2040-3372Publisher version
Language
- en