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Using digital health technologies to understand the association between movement behaviors and interstitial glucose: Exploratory analysis

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posted on 08.06.2018 by Andrew Kingsnorth, Maxine E. Whelan, James Sanders, Lauren Sherar, Dale Esliger
© Andrew P Kingsnorth, Maxine E Whelan, James P Sanders, Lauren B Sherar, Dale W Esliger. Background: Acute reductions in postprandial glucose excursions because of movement behaviors have been demonstrated in experimental studies but less so in free-living settings. Objective: The objective of this study was to explore the nature of the acute stimulus-response model between accelerometer-assessed physical activity, sedentary time, and glucose variability over 13 days in nondiabetic adults. Methods: This study measured physical activity, sedentary time, and interstitial glucose continuously over 13 days in 29 participants (mean age in years: 44.9 [SD 9.1]; female: 59%, 17/29; white: 90%, 26/29; mean body mass index: 25.3 [SD 4.1] ) as part of the Sensing Interstitial Glucose to Nudge Active Lifestyles (SIGNAL) research program. Daily minutes spent sedentary, in light activity, and moderate to vigorous physical activity were associated with daily mean glucose, SD of glucose, and mean amplitude of glycemic excursions (MAGE) using generalized estimating equations. Results: After adjustment for covariates, sedentary time in minutes was positively associated with a higher daily mean glucose (mmol/L; beta=0.0007; 95% CI 0.00030-0.00103; P < .001), SD of glucose (mmol/L; beta=0.0006; 95% CI 0.00037-0.00081; P < .001), and MAGE (mmol/L; beta=0.002; 95% CI 0.00131-0.00273; P < .001) for those of a lower fitness. Additionally, light activity was inversely associated with mean glucose (mmol/L; beta=−0.0004; 95% CI −0.00078 to −0.00006; P=.02), SD of glucose (mmol/L; beta=−0.0006; 95% CI −0.00085 to −0.00039; P < .001), and MAGE (mmol/L; beta=−0.002; 95% CI −0.00285 to −0.00146; P < .001) for those of a lower fitness. Moderate to vigorous physical activity was only inversely associated with mean glucose (mmol/L; beta=−0.002; 95% CI −0.00250 to −0.00058; P=.002). Conclusions: Evidence of an acute stimulus-response model was observed between sedentary time, physical activity, and glucose variability in low fitness individuals, with sedentary time and light activity conferring the most consistent changes in glucose variability. Further work is required to investigate the coupling of movement behaviors and glucose responses in larger samples and whether providing these rich data sources as feedback could induce lifestyle behavior change.

Funding

This work was funded in part by philanthropic support received from the late Dr the Honourable David Saul. The authors also acknowledge support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester National Health Service (NHS) Trust, Loughborough University and the University of Leicester, and the NIHR Collaboration for Leadership in Applied Health Research and Care East Midlands.

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Medical Internet Research

Volume

20

Issue

5

Citation

KINGSNORTH, A.P. ...et al., 2018. Using digital health technologies to understand the association between movement behaviors and interstitial glucose: Exploratory analysis. Journal of Medical Internet Research, mHealth and uHealth, 6(5):e114.

Publisher

© The Authors. Published by Journal of Medical Internet Research

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Publication date

2018

Notes

This is an Open Access Article. It is published by JMIR under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

eISSN

1438-8871

Language

en

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