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Control of batch and continuous crystallization processes using reinforcement learning
chapter
posted on 2021-07-19, 12:50 authored by Brahim BenyahiaBrahim Benyahia, Paul AnandanPaul Anandan, Chris RiellyChris RiellyIn crystallization processes, the control of particle size distribution, shape and purity are crucial to achieve the targeted critical quality attributes of the final drug product and meet the pharmaceutical regulatory requirements. This work presents novel optimal trajectory tracking control strategies for batch and continuous cooling crystallization processes using reinforcement learning (RL). The cooling crystallization of paracetamol in water was used as a case study. A model-based reinforcement learning technique is implemented to achieve large crystal size by reducing the deviation from targeted reference trajectories namely process temperature, supersaturation and particle size. This multioutput tracking control strategy was development to address quality and performance challenges commonly encountered in batch and continuous crystallization processes. Various training strategies and reward functions were investigated to enhance the learning capabilities and robustness of the reinforcement-learning-based control. Despite the computational costs inherent to reinforcement learning, the later demonstrated robust control capabilities compared the benchmark control strategies such as model predictive control.
Funding
ARTICULAR: ARtificial inTelligence for Integrated ICT-enabled pharmaceUticaL mAnufactuRing
Engineering and Physical Sciences Research Council
Find out more...History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
31st European Symposium on Computer Aided Process Engineering: ESCAPE-31Pages
1371 - 1376Source
31st European Symposium on Computer Aided Process Engineering (ESCAPE-31)Publisher
ElsevierVersion
- AM (Accepted Manuscript)
Rights holder
© ElsevierPublisher statement
This book chapter was accepted for publication in the book series Computer Aided Chemical Engineering, volume 50, and the definitive published version is available at https://doi.org/10.1016/B978-0-323-88506-5.50211-4.Acceptance date
2021-03-05Publication date
2021-07-18Copyright date
2021ISBN
9780323885065ISSN
1570-7946Publisher version
Book series
Computer Aided Chemical Engineering; 50Language
- en
Editor(s)
Metin Türkay; Rafiqul GaniLocation
Istanbul,TurkeyEvent dates
6th June 2021 - 9th June 2021Depositor
Dr Brahim Benyahia. Deposit date: 16 July 2021Usage metrics
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