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Decellularized vascular grafts

chapter
posted on 31.03.2021, 10:02 by Ria ToumpaniariRia Toumpaniari, Andres Hilfiker, Axel Haverich, Sotiris KorossisSotiris Korossis
Cardiovascular disease is one of the main causes of mortality and morbidity worldwide. The “gold standard” for the replacement/repair of diseased blood vessels is substitution with autologous vessels. However, multiple surgical procedures limit the availability of autologous vessels, whereas synthetic grafts have been reported to demonstrate poor patency rates, especially for small-caliber vascular reconstructions. Decellularization of native vascular or non-vascular tissues for vascular scaffold development has gained significant attention in the past 20 years. A variety of decellularization techniques have been described and employed to achieve effective immunogenic agent removal from the developed vascular scaffold. At the same time, the decellularization must not impair the extracellular matrix (ECM) composition, structure, and mechanical properties of the graft in order to ensure long-term functionality in vivo. The aim of this chapter was to review the various decellularization treatments that have been reported in the literature for the development of decellularized vascular scaffolds.

Funding

People Programme (Marie Curie Actions) of the EU 7th Framework Programme FP7/2007–2013/ under the TECAS-ITN (317512)

German Research Foundation through the Cluster of Excellence REBIRTH (EXC 62)

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Tissue-Engineered Vascular Grafts

Pages

207 - 269

Publisher

Springer

Version

AM (Accepted Manuscript)

Rights holder

© Crown

Publisher statement

This book chapter was published in the book Tissue-Engineered Vascular Grafts [© Crown]. The final authenticated version is available online at: https://doi.org/10.1007/978-3-030-05336-9_8.

Publication date

2020-08-21

Copyright date

2020

ISBN

9783030053369; 9783030053352

Book series

Reference Series in Biomedical Engineering

Language

en

Editor(s)

Beat H. Walpoth; Helga Bergmeister; Gary L. Bowlin; Deling Kong; Joris I. Rotmans; Peter Zilla

Depositor

Prof Sotiris Korossis. Deposit date: 28 March 2021

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