File(s) under permanent embargo

Reason: Publisher requirement.

Systematic model-based dynamic optimization of a combined cooling and antisolvent multistage continuous crystallization process

chapter
posted on 19.07.2021, 10:55 by Jiaxu Liu, Brahim Benyahia
A rigorous and systematic methodology was developed to optimize multistage combined cooling and antisolvent continuous MSMPR (mixed-suspension, mixed-product removal) crystallizers. The crystallization of aspirin (acetylsalicylic acid, ASA) in ethanol (solvent) and water (antisolvent) was used as a case study. A validated mathematical model of the system was firstly used to optimize the steady state performance followed by the development of several optimizations strategies aiming at the minimization of the start-up time using optimal dynamic profiles of antisolvent addition, cooling temperature, seeding flowrate and the combination of these decision variables. The start-up scenarios were also considered in the case of initially prefilled and empty vessels. Using the proposed dynamic optimization strategies, it was predicted that the start-up time can be reduced by up to 70%, which represents a significant gain in time, cost and environmental performance.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Computer Aided Chemical Engineering

Volume

50

Pages

1221 - 1227

Source

31st European Symposium on Computer Aided Process Engineering (ESCAPE-31)

Publisher

Elsevier

Version

AM (Accepted Manuscript)

Rights holder

© Elsevier

Publisher statement

This book chapter was accepted for publication in the book Computer Aided Chemical Engineering, volume 50, and the definitive published version is available at https://doi.org/10.1016/B978-0-323-88506-5.50188-1.

Acceptance date

05/03/2021

Publication date

2021-07-18

Copyright date

2021

ISBN

9780323885065

ISSN

1570-7946

Book series

Computer Aided Chemical Engineering; 50

Language

en

Editor(s)

Metin Türkay; Rafiqul Gani

Location

Istanbul,Turkey

Event dates

6th June 2021 - 9th June 2021

Depositor

Dr Brahim Benyahia. Deposit date: 16 July 2021