Electrospun Polycaprolactone Nano-fibers Supports Growth of Human Mesenchymal Stem Cells_Andrea Fotticchia.pdf (499.34 kB)
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Electrospun polycaprolactone nano-fibers supports growth of human mesenchymal stem cells

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conference contribution
posted on 24.01.2014 by Andrea Fotticchia, Yang Liu, Emrah Demirci, Cristina Lenardi
Electrospun polycaprolactone (PCL) layers with sub-micron fibres arranged in random, semi-aligned and aligned manners were prepared and their anisotropic mechanical property were further characterised at various stretching angle. Proof of principle study was carried out to assess biocompatibility of electrospun layers with human mesenchymal stem cells (hMSCs). Cell adhesion, viability and orientation outcomes showed that aligned PCL nano-fibers can be applied as a template to guide the alignment of hMSCs and could be a promising scaffold for tissue engineering of anisotropic annulus fibrosus in spinal inter-vertebral disc.

Funding

Research supported by Loughborough University graduate school PhD studentship (AF) and Royal Society.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Citation

FOTTICCHIA, A. ... et al., 2013. Electrospun polycaprolactone nano-fibers supports growth of human mesenchymal stem cells. IN: Proceedings of the 13th IEEE International Conference on Nanotechnology, Beijing, China, 5-8 August 2013, 4pp, doi: 10.1109/NANO.2013.6720851

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© IEEE

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AM (Accepted Manuscript)

Publication date

2013

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en

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