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A multi-physics theoretical and CFD approach, to predict low-GWP pMDI spray characteristics, inside USP-IP geometry

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conference contribution
posted on 2023-12-12, 14:44 authored by Hossain Chizari, Hendrik VersteegHendrik Versteeg, Weeratunge MalalasekeraWeeratunge Malalasekera, Barzin Gavtash

This paper presents the development of a comprehensive mathematical model aimed at predicting pressurized metered-dose inhaler (pMDI) unwanted drug deposition, using low global warming potential (GWP) propellant. The model incorporates various factors such as the geometric dimensions of pMDI’s actuator/valve and the properties of the formulation such as propellant, excipient, and drug load. The model successfully predicts the drug deposition on the actuator and the USP-IP, and, hence, the delivered fraction to the NGI/ACI. These predictions are validated through laboratory testing.

Funding

Innovate UK Knowledge Transfer Partnership KTP012178

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Drug Delivery to the Lungs Proceedings

Volume

34

Source

Drug Delivery to the Lungs (DDL 2023)

Publisher

The Aerosol Society

Version

  • VoR (Version of Record)

Rights holder

© Drug Delivery to the Lungs

Publisher statement

This paper was presented at the conference Drug Delivery to the Lungs (DDL 2023), Edinburgh, Scotland, UK, 6th - 8th December 2023. The Drug Delivery to the Lungs (DDL) Conference Papers Archive is available at https://ddl-conference.com/conference-papers/

Acceptance date

2023-11-15

Publication date

2023-12-11

Copyright date

2023

Language

  • en

Location

Edinburgh, Scotland, UK

Event dates

6th December 2023 - 8th December 2023

Depositor

Prof Weeratunge Malalasekera. Deposit date: 12 December 2023

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