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A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process
conference contributionposted on 2018-12-12, 11:39 authored by Seyed Soheil Mansouri, Isuru A. Udugama, Jakob K. Huusom, Krist V. Gernaey, Brahim BenyahiaBrahim Benyahia
In this work, a plant-wide model-based shortcut approach for decision-making and operational analysis of integrated end-to-end continuous pharmaceutical processes is developed and tested. The proposed hierarchical approach is implemented through a computer-aided framework. Using concepts of Layer of Protection Analysis (LOPA) combined with Net Present Value (NPV) are embedded in the framework from a model-based point of view to comprehensively assess the overall benefits of a specific operational point. This in turn can be used to make an informed decision between competing operation alternatives. The application of the framework is demonstrated through a validated dynamic process model of an integrated end-to-end continuous pharmaceutical pilot plant. In this application, the implications of changing process operations from single pass operation to raw material recycling have been investigated.
The project received financial support from Innovation Fund Denmark through the BIOPRO2 strategic research center (Grant number 4105-00020B).
- Aeronautical, Automotive, Chemical and Materials Engineering
- Chemical Engineering
Published inComputer Aided Chemical Engineering
Pages2107 - 2112
CitationMANSOURI, S.S. ... et al, 2018. A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process. IN: Eden, M.R., Ierapetritou, M.G. and Towler, G.P. (eds). 13th International Symposium on Process Systems Engineering (PSE 2018), San Diego, California, USA, 1-5 July 2018, pp.2107-2112.
- AM (Accepted Manuscript)
Publisher statementThis work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/
NotesThis conference paper is closed access.
Book seriesComputer Aided Chemical Engineering;44