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A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process
conference contributionposted on 2018-12-12, 11:39 authored by Seyed Soheil Mansouri, Isuru A. Udugama, Jakob K. Huusom, Krist V. Gernaey, Brahim BenyahiaBrahim Benyahia
In this work, a plant-wide model-based shortcut approach for decision-making and operational analysis of integrated end-to-end continuous pharmaceutical processes is developed and tested. The proposed hierarchical approach is implemented through a computer-aided framework. Using concepts of Layer of Protection Analysis (LOPA) combined with Net Present Value (NPV) are embedded in the framework from a model-based point of view to comprehensively assess the overall benefits of a specific operational point. This in turn can be used to make an informed decision between competing operation alternatives. The application of the framework is demonstrated through a validated dynamic process model of an integrated end-to-end continuous pharmaceutical pilot plant. In this application, the implications of changing process operations from single pass operation to raw material recycling have been investigated.
The project received financial support from Innovation Fund Denmark through the BIOPRO2 strategic research center (Grant number 4105-00020B).
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