Design and optimization of a multi-stage continuous crystallization process for shape and size control in presence of impurities [Extended abstract]

A combined experimental and model-based approach is used to design and optimize a multistage continuous crystallization of mefenamic acid (MFA) in presence of multiple impurities. A mathematical model was built and validated based of well-designed experiments which capture the impact of wide range of impurities. A novel design strategy that mimics temperature cycling was proposed to maximize and minimize the final crystal size.