Development of a theoretical model to predict pMDI spray force using alternative propellant systems-DDL2018R.pdf (170.87 kB)
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Development of a theoretical model to predict pMDI spray force, using alternative propellant systems

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conference contribution
posted on 08.10.2018, 13:54 by Barzin Gavtash, Andy Cooper, Sarah Dexter, C.G. Blatchford, Hendrik VersteegHendrik Versteeg
Continued success in the treatment of asthma and COPD requires new pMDI propellants for delivering aerosols with good patient comfort and acceptable levels of oral cavity deposition. The purpose of this work is to develop a theoretical model capable of predicting pMDI spray force as a function of metering valve geometric parameters and different propellant systems: HFA134a, HFA227ea and HFA152a. Such theoretical tool can be used in combination with lab-based measurements for device characterisation and potentially to reduce the number of experimental trials. The outcome of the model is compared against measurements of plume force with Copley Scientific Spray Force Tester SFT 1000. Results suggest that the size of the spray orifice has a significant direct effect on the spray force. We have also observed HFA134a and HFA152a generates similar magnitude of spray force and velocity where HFA227ea generates the lowest velocity and force values. These findings could potentially mean HFA152a sprays are expected to show similar levels of mouth-throat deposition to HFA134a sprays rather than HFA227ea sprays.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Drug Delivery to the Lungs (DDL2018)

Citation

GAVTASH, B. ... et al, 2018. Development of a theoretical model to predict pMDI spray force, using alternative propellant systems. Presented at the Drug Delivery to the Lungs conference 2018 (DDL2018), Edinburgh, UK, 12-14 December 2018.

Publisher

© The Aerosol Society

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

24/09/2018

Publication date

2018

Notes

This is a conference paper.

Language

en

Location

Edinburgh

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Keywords

Exports