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Effects of exercise-induced increases in body temperatures on local skin thermal sensitivity in Multiple Sclerosis patients

conference contribution
posted on 07.12.2016, 16:46 by Davide Filingeri, Georgia K. Chaseling, Phu Hoang, Michael Barnett, Scott L. Davis, Oliver E. Jay
Exercise and concomitant increases in body temperature reduces local skin thermal sensitivity via hypothesized analgesic-effects. Abnormal thresholds for thermal sensations and heat-sensitivity are well-established symptoms and modulatory factors, respectively, of Multiple Sclerosis. However, it is unknown whether increases in body temperature modulate sensory abnormalities in MS. We therefore investigated the hypothesis that changes in local skin thermal sensitivity are reduced in relapsing-remitting MS patients during cycling in the heat (30°C; 35%RH). Seven MS patients (age 54±7 y; body mass 76.1±10.9 kg; body surface area 1.9±0.2 m2), with increased warmth thresholds (0.61±0.58°C) compared to 4 age-, mass- and body surface area-matched healthy controls (CTR) (53±9 y; 75.6±14.0 kg; 1.9±0.2 m2; warmth threshold: 0.38±0.25°C); were asked to perform 30-min cycling at an intensity of 3.3 W/kg of total body mass. A quantitative thermo-sensory test, consisting of reporting (visual analogue scale) perceived magnitude of local warm (38°C) and cold (22°C) thermal stimuli (25 cm2-thermal probe) applied to the dorsum of the hand, was performed before and after every 10 min of cycling. Rectal temperature increased similarly between MS (+0.20±0.17°C) and CTR (+0.15±0.09°C) (p=0.619), whereas changes in mean skin temperature were greater in MS (1.41±0.38°C) than CTR (0.96±0.28°C) (p=0.077). 30 min of cycling reduced CTR thermo-sensitivity to warm (−10.5±10.0%) and cold (−14.1±8.5%) thermal stimuli. MS patients also experienced exercise-induced reductions in local thermo-sensitivity, however these were of smaller magnitude, both for warm (−2.7±16.4%) and cold (−10.4±8.6%) thermal stimuli. In line with previous research, exercise-induced increases in body temperature reduce skin thermo-sensitivity providing an analgesic effect in healthy controls. However, MS diminishes the magnitude of such effect.

Funding

Support or Funding Information This study was supported by a MS Research Australia Incubator Grant (Holders: Jay, Barnett, Hoang and Davis) and a University of Sydney International Collaboration research Award (IRCA) (Holders: Davis and Jay). Dr Filingeri was supported by a Government of Australia Endeavour Fellowship

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Published in

Experimental Biology 2016 The FASEB Journal

Volume

30

Issue

no. 1 Supplement

Pages

1243.16-1243.16 - 1243.16-1243.16

Citation

FILINGERI, D. ... et al, 2016. Effects of exercise-induced increases in body temperatures on local skin thermal sensitivity in Multiple Sclerosis patients. The FASEB Journal, 30 (no. 1 Supplement), p.1243.16

Publisher

Federation of American Society of Experimental Biology (FASEB)

Version

NA (Not Applicable or Unknown)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

01/04/2016

Publication date

2016

Notes

This abstract is from the Experimental Biology 2016 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

ISSN

0892-6638

eISSN

1530-6860

Language

en

Location

San Diego

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