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WCCM2022 Mechanical Stimuli in Prediction of Trabecular Bone Adaptation - Numerical Comparison.pdf (997.42 kB)

Mechanical stimuli in prediction of trabecular bone adaptation: numerical comparison

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conference contribution
posted on 2024-01-08, 10:24 authored by Ekaterina SmotrovaEkaterina Smotrova, Simin LiSimin Li, Vadim SilberschmidtVadim Silberschmidt
Adaptation is the process, with which bone responds to changes in loading environment and modifies its properties and organisation to meet the mechanical demands. Trabecular bone undergoes significant adaptation when subjected to external forces, accomplished through resorption of old and fractured bone and formation of a new bone material. These processes are assumed to be driven by mechanical stimuli of bone-matrix deformation sensed by bone mechanosensory cells. Although numerous in vivo and in vitro experimental evidence of trabecular bone morphology adaptation was obtained, the exact nature of mechanical stimuli triggering biological responses (i.e., osteoclastic resorption and osteoblastic formation) is still debated. This study aims to compare different mechanical stimuli with regard to their ability to initiate the load-induced adaptation in trabecular bone. For this purpose, a 2D model of two trabeculae, connected at their basement, with bone marrow in the intertrabecular space was developed. The finite-element method was implemented for the model loaded in compression to calculate magnitudes of several candidates of the bone-adaptation stimuli. A user material subroutine was developed to relate a magnitude of each candidate to changes in the shape of trabeculae.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

WCCM-APCOM 2022: Proceedings of the 15th World Congress on Computational Mechanics (WCCM-XV) and 8th Asian Pacific Congress on Computational Mechanics (APCOM-VIII)

Source

15th World Congress on Computational Mechanics (WCCM-XV) and 8th Asian Pacific Congress on Computational Mechanics (APCOM-VIII) (WCCM-APCOM 2022)

Publisher

CIMNE (International Centre for Numerical Methods in Engineering)

Version

  • VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by CIMNE under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Licence (CC BY-NC-SA). Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-sa/4.0/

Publication date

2022-06-30

Copyright date

2022

ISBN

9788412322286

ISSN

2938-4737

Language

  • en

Editor(s)

Seiichi Koshizuka

Location

Yokohama, Japan (Virtual)

Event dates

31st July 2022 - 5th August 2022

Depositor

Prof Vadim Silberschmidt. Deposit date: 1 January 2024

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