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Download fileSeparation of pharmaceutical products with reverse micelles
conference contribution
posted on 2009-07-01, 13:45 authored by Siti H. Mohd-Setapar, Richard J. Wakeman, Steve TarletonReverse micelle extraction has received considerable attention in recent years due to its ability to
selectively solubilise solutes from an aqueous phase and to maintain their biological activities.
This paper presents the results from studies on extraction of penicillin G from aqueous solution
(forward extraction) and from reverse micelles to a new aqueous solution (backward extraction), by
employing the principle of liquid-liquid extraction with reverse micelles. AOT is used as a
surfactant and isooctane is used as an organic phase. The effect of pH, salt concentration, AOT
concentration, and initial penicillin concentration on the penicillin forward and backward transfer at
21ºC was studied. The results show that the solubilisation of penicillin in the forward extraction is
dependent on both pH and surfactant concentration. The backward extraction is dependent on
ionic strength, surfactant concentration and the initial amount of penicillin in the organic phase
before backward extraction. Despite successful results in the backward extraction, the overall
extraction yield of penicillin is found to be less than the initial amount of penicillin before forward
extraction due to difficulties during the forward extraction process.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Citation
MOHD-SETAPAR, S.H., WAKEMAN, R.J. and TARLETON, E.S., 2008. Separation of pharmaceutical products with reverse micelles. 10th World Filtration Congress, 14-18 April, Leipzig, Germany.Publisher
Filtech Exhibitions GermanyVersion
- AM (Accepted Manuscript)
Publication date
2008Notes
This is a conference paper presented at WFC10 – April 14-18, 2008 in Leipzig Germany: http://www.wfc10.com/Language
- en