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Simulation based optimization of microneedle geometry to improve drug permeability in skin

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conference contribution
posted on 09.07.2009, 12:36 by Ololade Olatunji, Diganta DasDiganta Das, Barrak Al-Qallaf
Microneedles are a method of transdermal drug delivery which overcomes the barrier of the stratum corneum by piercing through with little or no pain. Microneedle have been shown to increase the skin permeability but the extent to which they do so is affected by the design of the microneedles due to certain parameters such as tip radius, base radius, pitch, number of microneedles on the patch and penetration depth. In this study a framework is developed to optimize these parameters and an optimum geometry for a microneedle shape is proposed. Simulations using two different softwares where then carried out to analyze the effect of these parameters on the diffusive flux and concentration of the drug in the blood. We found that the results of the numerical optimization and the results from the computer simulations led to the same conclusion about the optimum dimensions for the chosen geometry.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

OLATUNJI, O., DAS, D.B. and AL-QALLAF, B., 2009. Simulation based optimization of microneedle geometry to improve drug permeability in skin. IN: Proceedings of the 7th Industrial Simulation Conference' 2009 (ISC'2009), Loughborough, UK, pp. 293-300

Publisher

© Eurosis

Version

AM (Accepted Manuscript)

Publication date

2009

Notes

This is a conference paper. It is also available at: http://www.eurosis.org/cms/?q=node/905

ISBN

9789077381489

Language

en

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