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20210805 AMMM2021_BinZhang_ShortPaper.pdf (521.73 kB)

The development of Hypromellose based semisolid 3D printing inks for drug delivery

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conference contribution
posted on 2021-09-20, 08:57 authored by Bin Zhang, Xinyi Teoh, Peter Belton, Andy GleadallAndy Gleadall, Richard Bibb, Sheng Qi
3D printing is a promising method for producing medicines to tailor individual patient’s needs in the optimal dose and drug combinations which subsequently leads to enhanced therapeutic outcomes. Here, we developed semisolid ink formulations based on hydroxypropyl methylcellulose (HPMC). We investigated the effects of additives including PVP and SiO2 and a model drug, paracetamol, on the HPMC ink rheology behaviour and shape fidelity when produced using semisolid 3D extrusion printing. The formulations were extruded from the printing nozzle and laminated layer-by-layer. The current study presents novel drug-loaded HPMC-based inks for 3D construct fabrication for potential drug delivery applications.

Funding

UK Engineering and Physical Sciences Research Council (EPSRC) (Ref. EP/T014970/1)

History

School

  • Design and Creative Arts
  • Mechanical, Electrical and Manufacturing Engineering

Department

  • Design

Published in

Transactions on Additive Manufacturing Meets Medicine

Volume

3

Issue

1

Source

Additive Manufacturing Meets Medicine 2021

Publisher

Infinite Science

Version

  • VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Infinite Science under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

2021-08-05

Publication date

2021-09-08

Copyright date

2021

ISSN

2699-1977

Language

  • en

Location

Online

Event dates

8th September 2021 - 10th September 2021

Depositor

Prof Richard Bibb. Deposit date: 5 August 2021

Article number

541

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