These are the supporting data files for the article "The role of residence time distribution in the continuous steady-state MSMPR crystallization of glycine".
In this work, a vacuum-driven intermittent transfer technique has been implemented to solve transfer line
blockage issues and facilitate steady-state cooling crystallization studies of 𝛼-glycine in a single- and 2-stage MSMPR
crystallizer. Experimental residence time distribution (RTD) analysis of the stirred tank MSMPR cascade is performed
using an imperfect pulse method of the axial dispersion model to benchmark the mixing performance against that of
tubular crystallizers and determine the influence of RTD on steady-state size distribution of 𝛼-glycine product. Process
analytical technology (PAT) is used to monitor and understand crystallization process dynamics, and the effect of
MSMPR operating temperature, mean residence time, and number of MSMPR stages on mean particle size, crystal
size distribution, and yield is studied. Results show the significance of nucleation and growth mechanisms alongside
RTD in determining steady-state size distribution, and the need for optimum control of supersaturation to benefit from
improved RTDs provided by multistage MSMPR crystallizers.
Doctoral Training Centre in Continuous Manufacturing and Crystallisation
Engineering and Physical Sciences Research Council