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Supplementary information files for "A replicate crossover trial on the inter-individual variability of sleep indices in response to acute exercise undertaken by healthy men"

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posted on 2025-01-27, 12:40 authored by Yuting Yang, Alice ThackrayAlice Thackray, Tonghui Shen, Tareq F Alotaibi, Turki Alanazi, Tom CliffordTom Clifford, Iuliana HartescuIuliana Hartescu, James KingJames King, Scott WillisScott Willis, Matthew RobertsMatthew Roberts, Lorenzo Lolli, Greg Atkinson, David StenselDavid Stensel

Supplementary files for article "A replicate crossover trial on the inter-individual variability of sleep indices in response to acute exercise undertaken by healthy men"

Study objective: Using the necessary replicate-crossover design, we investigated whether there is inter-individual variability in home-assessed sleep in response to acute exercise.


Methods: Eighteen healthy men (mean(SD): 26(6) years) completed two identical control (8-h laboratory rest, 08:45-16:45) and two identical exercise (7-h laboratory rest; 1-h laboratory treadmill run [62(7)% peak oxygen uptake], 15:15-16:15) trials in randomised sequences. Wrist-worn actigraphy (MotionWatch 8) measured home-based sleep (total sleep time, actual wake time, sleep latency, sleep efficiency) two nights before (nights 1-2) and three nights after (nights 3-5) the exercise/control day. Pearson’s correlation coefficients quantified the consistency of individual differences between the replicates of control-adjusted exercise responses to explore: (1) immediate (night 3 minus night 2); (2) delayed (night 5 minus night 2); and (3) overall (average post-intervention minus average pre-intervention) exercise- related effects. Within-participant linear mixed models and a random-effects between- participant meta-analysis estimated participant-by-trial response heterogeneity.


Results: For all comparisons and sleep outcomes, the between-replicate correlations were non-significant, ranging from trivial-to-moderate (r range = -0.44 to 0.41, P≥0.065). Participant-by-trial interactions were trivial. Individual differences SDs were small, prone to uncertainty around the estimates indicated by wide 95% confidence intervals and did not provide support for true individual response heterogeneity. Meta-analyses of the between-participant, replicate-averaged condition effect revealed that, again, heterogeneity (τ) was negligible for most sleep outcomes.


Conclusion: Control-adjusted sleep in response to acute exercise was inconsistent when measured on repeated occasions. Inter-individual differences in sleep in response to exercise4 were small compared to the natural (trial-to-trial) within-subject variability in sleep outcomes.


© The Authors, CC BY-NC-ND 4.0

Funding

King Saud bin Abdulaziz University for Health Sciences (Saudi Arabia)

National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre (United Kingdom)

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  • Sport, Exercise and Health Sciences

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