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TMAO and Intermittent Exercise: Raw Data

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posted on 2024-10-01, 09:06 authored by Marilyn Ong Li Yin, Christopher Green, Samantha RowlandSamantha Rowland, Katie Rider, Harry Sutcliffe, Andrea Salzano, Liam HeaneyLiam Heaney

Raw data for circulating TMAO and choline values analysed by LC-MS/MS following either an intermittent exercise or time-matched resting control period.

Article abstract:

Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown. This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort. Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period. This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.

Funding

Ministry of Higher Education Malaysia and Universiti Sains Malaysia Post-Doctoral Fellowship

Loughborough University Doctoral Research Scholarship

ADM Biopolis

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  • Sport, Exercise and Health Sciences

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4835

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