The Lancet Gastroenterology & Hepatology Journal Cover September 1st 2017

High resolution manometry with a solid test meal increases diagnostic sensitivity for clinically relevant, symptomatic oesophageal motility disorders. The diagnosis of oesophageal motility disorders for high-resolution manometry (HRM) is based on ten single water swallows (SWS); however, this may not be representative of oesophageal function during ingestion of normal food. The primary aim of this study was to test the hypothesis that inclusion of a standardized solid test meal (STM) to HRM studies increases test sensitivity for major motility disorders. Additionally, the frequency and cause of patient symptoms during STM was assessed.