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A validated model of GAG deposition, cell distribution, and growth of tissue engineered cartilage cultured in a rotating bioreactor

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journal contribution
posted on 15.10.2013 by Nikolay Nikolaev, B. Obradovic, Hendrik Versteeg, G. Lemon, David Williams
The purpose of this article is to review the different strategies for the delivery of plasmid DNA (pDNA)-based gene therapy. Plasmids are extrachromosomal DNA capable of being transmitted from cell to cell. They are supercoiled, circular covalently closed (ccc) strands of DNA capable of replication independently of host DNA and ranging from 5 to 400 kilo base pairs (kb) in size, depending on the size of the therapeutic gene insert.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Citation

NIKOLAEV, N.I. ... et al, 2010. A validated model of GAG deposition, cell distribution, and growth of tissue engineered cartilage cultured in a rotating bioreactor. Biotechnology and Bioengineering, 105 (4), pp.842-853.

Publisher

© John Wiley and Sons

Version

SMUR (Submitted Manuscript Under Review)

Publication date

2010

Notes

This is the pre-peer reviewed version of the article which has been published in final form at: http://dx.doi.org/10.1002/bit.22581

ISSN

0006-3592

Language

en

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