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Advances and perspectives in aptamer arrays

journal contribution
posted on 02.01.2013, 12:26 by William Rowe, Mark Platt, Philip J.R. Day
Aptamers are oligonucleotides (typically 10–60 bases in length) capable of binding target ligands with affinities similar to antibodies. The generation of high density multiplexed aptamer arrays for molecular diagnostics was first proposed nearly ten years ago for the quantification of the thousands of proteins within biological samples, including blood and urine. The tagless aptameric detection of small molecular compounds extends the application of such arrays to bioanalyses at the metabolite level. We present here a minireview on some existing technologies and highlight recent innovations that are being applied to this field, which may facilitate the vision of highly multi-parallelized arrays for the quantitative analysis of biological systems.

History

School

  • Science

Department

  • Chemistry

Citation

ROWE, W., PLATT, M. and DAY, P.J.R., 2009. Advances and perspectives in aptamer arrays. Integrative Biology, 1 (1), pp.53-58.

Publisher

© Royal Society of Chemistry

Version

NA (Not Applicable or Unknown)

Publication date

2009

Notes

This article is closed access.

ISSN

1757-9694

Language

en

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