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An overview of current techniques for ocular toxicity testing

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posted on 18.11.2016 by Sammy Wilson, Mark Ahearne, Andrew Hopkinson
Given the hazardous nature of many materials and substances, ocular toxicity testing is required to evaluate the dangers associated with these substances after their exposure to the eye. Historically, animal tests such as the Draize test were exclusively used to determine the level of ocular toxicity by applying a test substance to a live rabbit’s eye and evaluating the biological response. In recent years, legislation in many developed countries has been introduced to try to reduce animal testing and promote alternative techniques. These techniques include ex vivo tests on deceased animal tissue, computational models that use algorithms to apply existing data to new chemicals and in vitro assays based on two dimensional (2D) and three dimensional (3D) cell culture models. Here we provide a comprehensive overview of the latest advances in ocular toxicity testing techniques, and discuss the regulatory framework used to evaluate their suitability.

Funding

Funding from EPSRC Engineering, Tissue Engineering and Regenerative Medicine Fellowship (E-TERM, Grant number: EP/ 1017801/1) and the University of Nottingham HERMES Fellowship (Grant number: 13b/I9)

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Toxicology

Volume

327

Pages

32 - 46

Citation

WILSON, S.L., AHEARNE, M. and HOPKINSON, A., 2014. An overview of current techniques for ocular toxicity testing. Toxicology, 327, pp. 32-46.

Publisher

Elsevier © The Authors

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

Publication date

2014

Notes

This is an Open Access article. It is published by Elsevier under the Creative Commons Attribution 3.0 Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

ISSN

0300-483X

Language

en

Licence

Exports