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Asymmetric copper catalyzed azide-alkyne cycloadditions

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journal contribution
posted on 26.05.2016 by William D.G. Brittain, Benjamin Buckley, John S. Fossey
Since its discovery independently by Sharpless and Meldal in 2002, the copper-catalyzed azide–alkyne cycloaddition (CuAAC) has become a ubiquitous molecular linking platform. Easy access to substituted 1,4-triazoles can be exploited to engender asymmetry to a myriad of potentially useful targets in high yields. Utilizing the CuAAC to form chiral triazolic products in a single step is an attractive and powerful approach for the synthetic chemist. The area of asymmetric CuAAC is still in its infancy compared to more established asymmetric metal-mediated transformations; however, this leads to exciting challenges that need to be overcome to usher in the next era in the story of the triazole and click chemistry in general. This review details the steps taken into asymmetric CuAAC and the exciting results achieved thus far. [Note that diagrams accompany this abstract in the published version and can be found at http://dx.doi.org/10.1021/acscatal.6b00996.]

Funding

JSF thanks the Royal Society for support through an Industry Fellowship. JSF and BRB thank the Royal Society for a Research Grant that initiated their collaboration. JSF and WDGB thank the Royal Society for an International Joint Project Award to collaborate with Professor Eric Anslyn on aspects of the topic covered in this review.

History

School

  • Science

Department

  • Chemistry

Published in

ACS Catalysis

Citation

BRITTAIN, W., BUCKLEY, B. and FOSSEY, J., 2016. Asymmetric copper catalyzed azide-alkyne cycloadditions. ACS Catalysis, 6 (6), pp. 3629–3636.

Publisher

© American Chemical Society

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2016

Notes

This paper was accepted for publication in the journal ACS Catalysis and the definitive published version is available at http://dx.doi.org/10.1021/acscatal.6b00996.

ISSN

2155-5435

Language

en

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