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Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: a systematic review and meta-analysis

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posted on 23.01.2020 by Adam Causer, Janis Shute, Michael Cummings, Anthony Shepherd, Mathieu Gruet, Joseph Costello, Stephen Bailey, Martin Lindley, Clare Pearson, Gary Connett, Mark Allenby, Mary Carroll, Thomas Daniels, Zoe Saynor
Introduction: Oxidative stress may play an important role in the pathophysiology of cystic fibrosis (CF). This review aimed to quantify CF-related redox imbalances.
Methods: Systematic searches of the Medline, CINAHL, CENTRAL and PsycINFO databases were conducted. Mean content of blood biomarkers from people with clinically-stable CF and non-CF controls were used to calculate the standardized mean difference (SMD) and 95% confidence intervals (95% CI).
Results: Forty-nine studies were eligible for this review including a total of 1,792 people with CF and 1,675 controls. Meta-analysis revealed that protein carbonyls (SMD: 1.13, 95% CI: 0.48 to 1.77), total F2-isoprostane 8-iso-prostaglandin F2α (SMD: 0.64, 95% CI: 0.23 to 1.05) and malondialdehyde (SMD: 1.34, 95% CI: 0.30 to 2.39) were significantly higher, and vitamins A (SMD: -0.66, 95% CI -1.14 to -0.17) and E (SMD: -0.74, 95% CI: -1.28 to -0.20), β-carotene (SMD: -1.80, 95% CI: -2.92 to -0.67), lutein (SMD: -1.52, 95% CI: -1.83 to -1.20) and albumin (SMD: -0.98, 95% CI: -1.68 to -0.27) were significantly lower in the plasma or serum of people with CF versus controls.
Conclusions: This systematic review and meta-analysis found good evidence for reduced antioxidant capacity and elevated oxidative stress in people with clinically-stable CF.

Funding

University of Portsmouth

History

School

  • Sport, Exercise and Health Sciences

Published in

Redox Biology

Volume

32

Issue

May 2020

Publisher

Elsevier

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).

Acceptance date

16/01/2020

Publication date

2020-01-23

Copyright date

2020

ISSN

2213-2317

Language

en

Depositor

Dr Stephen Bailey. Deposit date: 20 January 2020

Article number

101436

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