Filingeri_MSSE revised manuscript_Cold Drink Ingestion-Revisions.pdf (393.99 kB)

Cold water ingestion improves exercise tolerance of heat-sensitive people with MS

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posted on 10.07.2018 by Georgia K. Chaseling, Davide Filingeri, Michael Barnett, Phu Hoang, Scott L. Davis, Oliver E. Jay
© 2018 Lippincott Williams and Wilkins. All rights reserved. Purpose Heat intolerance commonly affects the exercise capacity of people with multiple sclerosis (MS) during bouts of hot weather. Cold water ingestion is a simple cooling strategy, but its efficacy for prolonging exercise capacity with MS remains undetermined. We sought to identify whether cold water ingestion blunts exercise-induced rises in body temperature and improves exercise tolerance in heat-sensitive individuals with MS. Methods On two separate occasions, 20 participants (10 relapsing-remitting MS (expanded disability status scale, 2-4.5); 10 age-matched healthy controls) cycled at ∼40% VO 2max at 30°C and 30% relative humidity until volitional exhaustion (or a maximum of 60 min). Every 15 min, participants ingested 3.2 mL·kg -1 of either 1.5°C (CLD) or 37°C (NEU) water. Rectal (T re ) temperature, mean skin (T sk ) temperature, and heart rate (HR) were measured throughout. Results All 10 controls but only 3 of 10 MS participants completed 60 min of exercise in NEU trial. The remaining 7 MS participants all cycled longer (P = 0.006) in CLD (46.4 ± 14.2 min) compared with NEU (32.7 ± 11.5 min), despite a similar absolute T re (NEU: 37.32°C ± 0.34°C; CLD: 37.28°C ± 0.26°C; P = 0.44), change in T re (NEU: 0.38°C ± 0.21°C; CLD: 0.34°C ± 0.24°C), absolute T sk (NEU: 34.48°C ± 0.47°C; CLD: 34.44°C ± 0.54°C; P = 0.82), and HR (NEU: 114 ± 20 bpm; CLD: 113 ± 18 bpm; P = 0.38) for the same exercise volume. Conclusions Cold water ingestion enhanced exercise tolerance of MS participants in the heat by ∼30% despite no differences in T re , T sk or HR. These findings support the use of a simple cooling strategy for mitigating heat intolerance with MS and lend insight into the potential role of cold-afferent thermoreceptors that reside in the abdomen and oral cavity in the modulation of exercise tolerance with MS in the heat.

Funding

This research was supported by a Multiple Sclerosis Research Australia Incubator Grant (Grant holders: Jay, Davis, Barnett and Hoang; grant number #14-009); a Multiple Sclerosis Research Australia Postgraduate Fellowship (Grant holders: Chaseling and Jay; grant number #15-087); and an Australian Government, Department of Education, Endeavour Post-Doctoral Research Fellowship (Grant holder: Filingeri).

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Published in

Medicine and Science in Sports and Exercise

Volume

50

Issue

4

Pages

643 - 648

Citation

CHASELING, G.K. ...et al., 2018. Cold water ingestion improves exercise tolerance of heat-sensitive people with MS. Medicine and Science in Sports and Exercise, 50(4), pp. 643-648.

Publisher

© American College of Sports Medicine. Published by Wolters Kluwer

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

30/11/2017

Publication date

2018

Notes

This is a non-final version of an article published in final form in CHASELING, G.K. ...et al., 2018. Cold water ingestion improves exercise tolerance of heat-sensitive people with MS. Medicine and Science in Sports and Exercise, 50(4), pp. 643-648.

ISSN

0195-9131

eISSN

1530-0315

Language

en

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