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Comparison of external bulk video imaging with focused beam reflectance measurement and ultra-violet visible spectroscopy for metastable zone identification in food and pharmaceutical crystallization processes

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journal contribution
posted on 11.12.2009, 15:15 by Levente L. Simon, Zoltan Nagy, Konrad Hungerbuhler
The purpose of the paper is twofold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement (FBRM) and ultra violet/visible (UV/Vis) spectroscopy. While the latter two sample the system in small volumes closely to the probe, the BVI approach monitors the entire or large parts of the crystallizer volume. The BVI method is proposed as a complementary noninvasive PAT tool and it is shown that it is able to detect the boundaries of the metastable zone with comparable or better performance than the FBRM and UV/VIS probes.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

SIMON, L.L., NAGY, Z.K. and HUNGERBUHLER, K., 2009. Comparison of external bulk video imaging with focused beam reflectance measurement and ultra violet-visible spectroscopy for metastable zone identification in food and pharmaceutical crystallization processes. Chemical Engineering Science, 64 (14), pp. 3344-3351.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publication date

2009

Notes

This is a journal article. It was published in the Chemical Engineering Journal [© Elsevier] and the definitive version is available www.elsevier.com/locate/ces

ISSN

1385-8947

Language

en

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Keywords

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