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Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel

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journal contribution
posted on 21.06.2016, 12:18 by Alessandro Schiavone, C. Abunassar, S. Hossainy, Liguo Zhao
Crimping and deployment of bioresorbable polymeric scaffold, Absorb, were modelled using finite element method, in direct comparison with Co-Cr alloy drug eluting stent, Xience V. Absorb scaffold has an expansion rate lower than Xience V stent, with a less outer diameter achieved after balloon deflation. Due to the difference in design and material properties, Absorb also shows a higher recoiling than Xience V, which suggests that additional post-dilatation is required to achieve effective treatment for patients with calcified plaques and stiff vessels. However, Absorb scaffold induces significantly lower stresses on the artery-plaque system, which can be clinically beneficial. Eccentric plaque causes complications to stent deployment, especially non-uniform vessel expansion. Also the stress levels in the media and adventitia layers are considerably higher for the plaque with high eccentricity, for which the choice of stents, in terms of materials and designs, will be of paramount importance. Our results imply that the benefits of Absorb scaffolds are amplified in these cases.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Journal of Biomechanics

Citation

SCHIAVONE, A. ...et al., 2016. Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel. Journal of Biomechanics, 49 (13), pp. 2677-2683.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

01/06/2016

Publication date

2016-06-06

Notes

This paper was accepted for publication in the journal Journal of Biomechanics and the definitive published version is available at http://dx.doi.org/10.1016/j.jbiomech.2016.05.035

ISSN

1873-2380

Language

en

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