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Controlling polymer capture and translocation by electrostatic polymer-pore interactions

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journal contribution
posted on 19.10.2017 by Sahin Buyukdagli, Tapio Ala-Nissila
Polymer translocation experiments typically involve anionic polyelectrolytes such as DNA molecules driven through negatively charged nanopores. Quantitative modeling of polymer capture to the nanopore followed by translocation therefore necessitates the consideration of the electrostatic barrier resulting from like-charge polymer-pore interactions. To this end, in this work we couple mean-field level electrohydrodynamic equations with the Smoluchowski formalism to characterize the interplay between the electrostatic barrier, the electrophoretic drift, and the electro-osmotic liquid flow. In particular, we find that due to distinct ion density regimes where the salt screening of the drift and barrier effects occurs, there exists a characteristic salt concentration maximizing the probability of barrier-limited polymer capture into the pore. We also show that in the barrier-dominated regime, the polymer translocation time τ increases exponentially with the membrane charge and decays exponentially fast with the pore radius and the salt concentration. These results suggest that the alteration of these parameters in the barrier-driven regime can be an efficient way to control the duration of the translocation process and facilitate more accurate measurements of the ionic current signal in the pore.

History

School

  • Science

Department

  • Mathematical Sciences

Published in

J Chem Phys

Volume

147

Issue

11

Pages

114904 - 114904

Citation

BUYUKDAGLI, S. and ALA-NISSILA, T., 2017. Controlling polymer capture and translocation by electrostatic polymer-pore interactions. The Journal of Chemical Physics, 147 (11), 114904.

Publisher

AIP Publishing © The Authors

Version

VoR (Version of Record)

Acceptance date

11/09/2017

Publication date

2017

Notes

This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The following article appeared in The Journal of Chemical Physics, 147 (11), 114904 and may be found at https://doi.org/10.1063/1.5004182.

ISSN

0021-9606

eISSN

1089-7690

Language

en

Location

United States

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