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Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine

journal contribution
posted on 21.08.2017 by Elizabeth Ratcliffe, Rob Thomas, David Williams
BACKGROUND. A novel manufacturing industry is emerging to translate unique cellular therapy bioprocesses to robust, scaled manufacturing production for successful clinical translation. SOURCE OF DATA. This review summarizes key translational issues, and current and future perspectives to improve translation of cell-based therapy bioprocessing, based on literature search and author research. AREAS OF AGREEMENT. It is widely recognized that cell-based therapies could revolutionize health care for a range of diseases, and that there are gaps in the overarching framework and technologies to generate clinical success. AREAS OF CONTROVERSY. There is limited understanding of how to fulfil requirements as regulatory and manufacturing guidelines are incomplete and few have achieved commercialization. GROWING POINTS. Recent developments are encouraging adoption of automation and quality engineering approaches for bioprocessing of cell-based therapies. AREAS TIMELY FOR DEVELOPING RESEARCH. Include technology development to improve the cost and purity of manufacture and final product quality.

Funding

This work was supported by the UK Engineering and Physical Sciences Research Council-funded Centre for Innovative Manufacturing in Regenerative Medicine, which is a partnership of Loughborough, Nottingham and Keele Universities, and industry and the public sector stakeholders.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

British Medical Bulletin

Volume

100

Issue

1

Pages

137 - 155

Citation

RATCLIFFE, E., THOMAS, R. and WILLIAMS, D., 2011. Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine. British Medical Bulletin, 100 (1), pp.137-155.

Publisher

Oxford University Press (© the author)

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2011

ISSN

0007-1420

eISSN

1471-8391

Language

en

Exports